His studies have involved the correlation of focal lesions in the brain with subtle disorders of motor performance, previously undetected but now exposed and analysed in ingenious behavioural experiments.
12.
Much of what is understood about the functions of the cerebellum stems from careful documentation of the effects of focal lesions in human patients who have suffered from injury or disease or through animal lesion research.
13.
Other features include skeletal alterations ( osteolysis, osteoporosis ), amyotrophy ( wasting of muscle ), lipodystrophy and skin atrophy ( loss of subcutaneous tissue and fat ) with sclerodermatous focal lesions, severe atherosclerosis and prominent scalp veins.
14.
This mechanism offers that after a focal lesion of neurons in striate cortex, or following a retinal lesion depriving these neurons of visual input, the receptive fields of nearby healthy neurons converge to code information about contours of objects normally coded by the damaged neurons while still coding the same information about retinal location prior to the injury.
15.
Any type of focal lesion of the central nervous system ( such as stroke, brain tumor, multiple sclerosis ) will cause the type of ataxia corresponding to the site of the lesion : cerebellar if in the cerebellum, sensory if in the dorsal spinal cord ( and rarely in the thalamus or parietal lobe ), vestibular if in the vestibular system ( including the vestibular areas of the cerebral cortex ).
