For the cholera toxin, the principal glycolipid receptor for the cholera toxin is ganglioside GM1 . that is in the endoplasmic reticulum.
12.
9-O-acetyl GD3 ganglioside is an acetylated glycolipid which is found in the cell membranes of many types of vertebrate cells.
13.
For example, fluorophores conjugated to cholera-toxin B-subunit, which binds to the raft constituent ganglioside GM1 is used extensively.
14.
The name " ganglioside " was first applied by the German scientist Ernst Klenk in 1942 to lipids newly isolated from residues.
15.
Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses.
16.
Mutations in the " HEXB " gene disrupt the activity of these enzymes, preventing the breakdown of GM2 ganglioside and other molecules.
17.
This drug is a reversible inhibitor of the enzyme glucosylceramide synthase, which catalyzes the �rst step in synthesizing glucose-based glycosphingolipids like GM2 ganglioside.
18.
In humans the brain has the highest sialic acid concentration, where these acids play an important role in neural transmission and ganglioside structure in synaptogenesis.
19.
SV40 utilizes two different receptors to bind onto cell surface : ganglioside GM1 located in lipid rafts and major histocompatibility ( MHC ) class I molecule.
20.
Mutations in this gene may be involved in the development and progression of meningioma through modification of ganglioside composition and other glycosylated molecules in tumor cells.
