Experiments in different drug resistant cell lines and patient DNA revealed gene rearrangements that had initiated the activation or overexpression of " MDR1 ."
12.
Thymocytes that reach the medulla have already successfully undergone T cell receptor gene rearrangement and positive selection, and have been exposed to a limited degree of negative selection.
13.
By repairing DNA, these proteins play a role in maintaining the stability of the human genome and prevent dangerous gene rearrangements that can lead to hematologic and other cancers.
14.
In B lymphocytes, successful heavy chain gene rearrangement of the genetic material from one chromosome results in the shutting down of rearrangement of genetic material from the second chromosome.
15.
PMLBCL is CD20 positive, expresses pan-B markers including CD79a, and has clonal immunoglobulin gene rearrangements and mRNA but paradoxically does not express cytoplasmic or cell surface immunoglobulin.
16.
Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia ( APL ) and physiological roles have been identified in mouse Natural Killer T cells and gamma-delta T cells.
17.
PreBCR transduces signals for : 1 ) cellular proliferation, differentiation from the proB cell to preB cell stage, 2 ) allelic exclusion at the Ig heavy chain gene locus, and 3 ) promotion of Ig light chain gene rearrangements.
18.
Although expression is typically found to be in the primary lymphoid organs, recent work has suggested that stimulation via antigen can result in secondary TdT expression along with other enzymes needed for gene rearrangement outside of the thymus for T-cells.
19.
This involves the reactivation or maintenance of V ( D ) J recombination in the cell which leads to the expression of novel receptor specificity through V region gene rearrangements which will create variation in the heavy and light immunoglobulin ( Ig ) chains.
20.
They suggested that " control of lg gene rearrangement might be the only mechanism that determines the specificity of heavy chain gene expression within the lymphoid cell lineage . " in 1987, they created transgenic mice with the fused gene that developed fatal leukemia.
