These filters use minimotif complexity, protein surface location, molecular processes, cellular processes, protein-protein interactions, and genetic interactions.
12.
By examining 5.4 million gene-gene pairs for synthetic lethality, an unbiased network of functional connections between genetic interactions was constructed.
13.
Since many complex genetic interactions are necessary for neurons to perform the simplest tasks, it is hard to isolate one gene to study this behavior.
14.
A genome scale genetic interaction map was created by SGA analysis in " S . cerevisiae " that comprises about 75 % of all yeast genes.
15.
Currently, techniques for molecular characterization of disease mechanisms are established for many monogenic diseases, but these studies do not improve understanding of genetic interactions and their phenotypic implications.
16.
Tn-seq was used to determine genetic interactions between five query genes and the rest of the genome in Streptococcus pneumoniae, which revealed both aggravating and alleviating genetic interactions.
17.
Tn-seq was used to determine genetic interactions between five query genes and the rest of the genome in Streptococcus pneumoniae, which revealed both aggravating and alleviating genetic interactions.
18.
The answer most likely lies in the realm of genetic interactions, where genes work together to achieve complex ends, or in the complicated interactions of the proteins produced by the genes.
19.
Synthetic genetic array ( SGA ), synthetic lethality by microarray ( SLAM ), and genetic interaction mapping ( GIM ) are three high-throughput methods for analyzing synthetic lethality in yeast.
20.
High throughput methods of examining epistatic relationships face difficulties, however as the number of possible gene pairs is extremely large ( ~ 20 million in S . cerevisiae ) and the estimated density of genetic interactions is quite low.
