The circulating cells in the blood all come from the stem cells in the bone marrow; see haematopoiesis for details of this process.
12.
This disappearance correlates to the migration of these hematopoietic stem cells to the foetal liver, where it becomes the subsequent site of haematopoiesis.
13.
CD40 is also expressed on B cell precursors in the bone marrow, and there is some evidence that CD40-CD154 interactions may play a role in the control of B cell haematopoiesis.
14.
Notch1 knockouts exhibit normal haematopoiesis in the yolk sac, but fail to produce any HSCs in the AGM . Experiments have been shown that decreased Notch1 expression also affects the expression of Runx1, resulting in its downregulation.
15.
Other significant work by Bizzozero included research of haematopoiesis in the bone marrow, studies involving phagocytosis in the eye, and the identification of desmosomes ( nodes of Bizzozero ), structures that he first discovered in the stratum spinosum of epidermis.
16.
FANCA is hypothesised to play a crucial role in adult ( definitive ) haematopoiesis during embryonic development, and is thought to be expressed in all haematopoietic sites that contribute to the formation of haematopoietic stem cells and progenitor cells ( HSPCs ).
17.
In his research of haematopoiesis, Ferrata helped demonstrate the systemic nature of leukemia, leading him to support an hypothesis that elements of the blood ( erythrocytes, leukocytes, and blood platelets ) all originate from the hemocytoblast, a direct descendant of a mesenchymal cell, which he referred to as an " emoistioblasto " ( hemohistioblast ).
18.
2011 : " At the same time, blood stem cells were conceptualized by histologists such as Ernst Neumann and Artur Pappenheim in studies of physiological haematopoiesis and various forms of leukaemia . " " Ernst Neumann pointed to the first successes of Carrel in tissue culturing as a reason for his hope that blood cell cultures might in future be produced as well ( 1912, p . 382 )"
