In his clinical role, Woodruff started a vascular surgery program and worked with the use of immunotherapy as a cancer treatment as well as the treatment of autoimmune haemolytic anaemia.
12.
It is a unique glycolytic enzymopathy that is characterized by chronic haemolytic anaemia, cardiomyopathy, susceptibility to infections, severe neurological dysfunction, and, in most cases, death in early childhood.
13.
Anti-LW has also been associated with cases of warm type autoimmune haemolytic anaemia; Philip Levine suggested that it was the most common antibody in cases of AIHA with a positive Coombs test.
14.
The first signs of exposure, which can take several hours to become apparent, are headaches, vertigo and nausea, followed by the symptoms of haemolytic anaemia ( high levels of unconjugated bilirubin ), haemoglobinuria and nephropathy.
15.
Nitrofurantoin is also contraindicated in babies up to the age of one month, as they have immature enzyme systems in their red blood cells ( glutathione instability ), so nitrofurantoin must not be used because it can cause haemolytic anaemia.
16.
The research group's principal investigations concerned immunological tolerance ( the body's acceptance of tissues, as opposed to rejection ), autoimmune haemolytic anaemia ( especially in mice ), and immune responses to cancer in various animals.
17.
The difference between a normal red blood cell ( RBC ) and a red blood cell with unstable haemoglobin ( such as in the case of haemolytic anaemia ) is that, in a normal RBC, the formation of Heinz bodies is significantly delayed.
18.
His name is associated with the Widal test, a diagnostic test for typhoid fever, and with hematologist Georges Hayem ( 1841-1933 ), he described acquired haemolytic anaemia, a disease that was historically referred to as " Hayem-Widal syndrome ".
19.
In nonhuman animals, " Babesia canis rossi ", " Babesia bigemina ", and " Babesia bovis " cause particularly severe forms of the disease, including a severe haemolytic anaemia, with positive erythrocyte-in-saline-agglutination test indicating an immune-mediated component to the haemolysis.
20.
Antibodies to these specific antigens have been associated with a number of conditions : anti M2, M4, M8, and M9 are associated with primary bilary cirrhosis; M2-autoimmune hepatitis; M1-syphilis; M3-drug-induced lupus erythematosus; M6-drug-induced hepatitis; M7-cardiomyopathy, myocarditis; M5-systemic lupus erythematosus and undifferentiated collagenosis, autoimmune haemolytic anaemia.
