CYP2E1 metabolizes mostly small, polar molecules, including toxic laboratory chemicals such as dimethylformamide, aniline, and halogenated hydrocarbons " ( see table below ) ".
12.
The reaction between pure trialalkylaluminum compounds and water, alcohols, phenols, amines, carbon dioxide, sulfur oxides, nitrogen oxides, halogens, and halogenated hydrocarbons can be violent.
13.
Included in these are methanol, nitroglycerine, nitrocellulose, dimethylnitrosamine, and the halogenated hydrocarbons : methyl chloride, methyl bromide, trichloroethylene, carbon tetrachloride, and the chlorinated naphthalenes.
14.
All inhalation anesthetics in current clinical use are halogenated ethers, except for halothane ( which is a halogenated hydrocarbon or " haloalkane " ), nitrous oxide, and xenon.
15.
Methanotrophs also possess MMO, it is known that this enzyme has a broad substrate specificity and it can catalyzes the oxidation of a wide variety of water pollutants, such as trichloroethylene, vinyl chloride, and other halogenated hydrocarbons.
16.
Thomas Midgley ( who held a PhD and was the inventor of tetraethyl lead and halogenated hydrocarbon refrigerants ) said of trial and error, " the trick is to turn a wild goose chase into a fox hunt " ( quoted in Hughes 2004 ).
17.
Later, in 1930, He directly synthesized lithium alkyls and aryls from metallic lithium and halogenated hydrocarbons . 4Li + 2RX 2RLi This convenient synthesis spurred numerous studies of RLi reagents by others, and now organolithium reagents are one of the most versatile and valuable tools of the synthetic organic chemist.
18.
Contraindications for the use of ephedrine include : asymmetric septal hypertrophy ( idiopathic hypertrophic subaortic stenosis ), concomitant or recent ( previous 14 days ) monoamine oxidase inhibitor ( MAOI ) therapy, general anaesthesia with halogenated hydrocarbons ( particularly halothane ), tachyarrhythmias or ventricular fibrillation, or hypersensitivity to ephedrine or other stimulants.
19.
Anaesthesia related research themes have encompassed a very broad range of themes : metabolism and renal toxicity of inhalation anaesthetics, antibiotics and NSAIDs providing the first evidence with Richard Mazze in 1974 of organ toxicity of a drug metabolite ( published in Journal of Pharmacology & Experimental Therapeutics ) as well as multiple related papers; metabolism and hepatoxicity of halothane, utilizing basic and clinical studies to demonstrate both acute metabolite initiated toxicity and delayed metabolite-immune mediated hepatoxicity; toxicity of chronic inhalation of halogenated hydrocarbons; intravenous sedatives and anaesthetics pharmacokinetics, pharmacodynamics and side effects; local anaesthetic pharmacology; epidural and intrathecal neural blockade, pharmacologyy and physiology.
