The pK a for the quinoline nitrogen of chloroquine is 8.5, meaning it is about 10 % deprotonated at physiological pH as calculated by the Henderson-Hasselbalch equation.
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Not that you mentioned it, but you may find Buffer solution and Henderson Hasselbalch equation to be relevent reading .-- contribs 20 : 37, 8 May 2009 ( UTC)
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The ratio of these determines the color of the solution and connects the color to the pH value . pH indicators that are weak protolytes, the Henderson Hasselbalch equation for them can be written as:
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This is just a consequence of simple equilibrium principles-the Henderson-Hasselbalch equation may look magical, but it's just the talk ) 18 : 13, 2 April 2008 ( UTC)
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The larger the value of p " K " a, the smaller the extent of dissociation at any given pH ( see Henderson Hasselbalch equation ) that is, the weaker the acid.
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Patterned after chemistry's Henderson Hasselbalch equation for the pH of a solution, personology was a holistic approach that studied the person at many levels of complexity all at the same time by an interdisciplinary team of investigators.
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The ratio of acid, AH and conjugate base, A & minus;, concentrations varies as the difference between the pH and the p " K " a varies, in accordance with the Henderson-Hasselbalch equation.
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The Henderson-Hasselbalch equation can also be rearranged to calculate the net charge of an amino acid at a certain pH . If the Henderson-Hasselbalch was rewritten in terms of degree of dissociation, it would be written as follows:
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Finally, using the Henderson-Hasselbalch equation, and knowing the drug s pKa \, ( pH at which there is an equilibrium between its ionized and non ionized molecules ), it is possible to calculate the non ionized concentration of the drug and therefore the concentration that will be subject to absorption:
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The Henderson-Hasselbalch equation offers a way to determine the proportion of a substance that is ionized at a given pH . In the stomach, drugs that are weak acids ( such as aspirin ) will be present mainly in their non-ionic form, and weak bases will be in their ionic form.
