These worms are members of two phyla; nematodes, which are primarily used in human helminthic therapy, and flat worms.
12.
These pathogens include HIV-1, helminthic parasites such as schistosomes, and Helicobacter pylori, the bacterium that causes stomach ulcers.
13.
Helminthic therapy emerged from the search for reasons why the incidence of immunological disorders and autoimmune diseases correlates with the level of industrial development.
14.
Given the down regulation of Th1 and Th17 immune responses with helminthic therapy, immune responses to other pathogens and allergens may be suppressed.
15.
Crohn's is common in parts of the world where helminthic colonisation is rare and uncommon in those areas where most people carry worms.
16.
As such, helminthic therapy attempts to restore homeostasis by shifting a hyperactive Th1 pro-inflammatory response to a Th2 response with reduced inflammation.
17.
They produce a profile of signals in response to pro-allergenic cytokines IL-33 that is similar to those produced in response to helminthic infection.
18.
To date, occurrence of autoinfection in humans with helminthic infections is recognized only in " Strongyloides stercoralis " and " Capillaria philippinensis " infections.
19.
Anti-helminthic therapy is reserved for severe infections ( lungs, brain ) because therapy may induce, due to massive larval killing, a strong inflammatory response.
20.
Helminthic therapy using the whipworm " Trichuris suis " has been shown in a randomized control trial from Iowa to show benefit in patients with ulcerative colitis.
