It involved six patients with severe hemophilia A, a disorder caused when the gene for a blood-clotting protein, Factor VIII, fails to function.
12.
For instance, deficiency of Factor VIII causes classic Hemophilia A while deficiencies of Factor IX cause " Christmas disease " ( hemophilia B ).
13.
The human gene for Factor VIII, for example, is too large for it, so some other virus must be found to treat hemophilia A.
14.
The diagnosis of hemophilia A may be suspected as coagulation testing reveals an increased trauma ( i . e . tooth extraction, or surgery ).
15.
While in Iowa, Dr . Brinkhous carried out research on hemophilia as part of a research team that included several other physicians interested in coagulation.
16.
Nevertheless, patients with known bleeding disorders ( e . g ., hemophilia A ) or recent abnormal bleedings should be treated cautiously and under close medical supervision.
17.
Cohen said protein injections to curb hemophilia A represent a market of $ 1.6 billion in the United States, more than four times the market for hemophilia B.
18.
But the adeno-associated virus is small, so it apparently cannot carry large genes, like the one for Factor VIII, whose absence causes the much more common hemophilia A.
19.
Researchers tested the method on six men with severe hemophilia A, the most common type of the inherited disorder that afflicts about 15, 000 men in the United States.
20.
This partnership was extended the following year to also include the development of a long-lasting recombinant factor VIII Fc fusion protein candidate, rFVIIIFc, for the treatment of hemophilia A.
