To test whether homophilic binding of Dscam1 isoforms is required for self-avoidance, Wu and coworkers generated pairs of chimeric isoforms that bind to each other ( heterophilic ) but not to themselves ( homophilic ).
12.
The extracellular domains of these proteins form the tight junction barrier by making homophilic ( between proteins of the same kind ) and heterophilic interactions ( between different types of proteins ) with the protein domains on adjacent cells.
13.
Homophilic adhesion involves the immunoglobulin-like domains on the cell surface binding to the immunoglobulin-like domains on an opposing cell s surface while heterophilic adhesion refers to the binding of the immunoglobulin-like domains to integrins and carbohydrates instead.
14.
Neuroligins bind with the aid of Ca 2 + to the ?-neurexin LNS ( laminin, neurexin and sex hormone-binding globulin-like folding units ) domains and to the ?-neurexin LNS domain which then establishes a heterophilic trans-synaptic recognition code.
15.
These proteins are typically transmembrane receptors and are composed of three domains : an intracellular domain that interacts with the cytoskeleton, a transmembrane domain, and an extracellular domain that interacts either with other CAMs of the same kind ( "'homophilic "'binding ) or with other CAMs or the extracellular matrix ( "'heterophilic "'binding ).
