When a capacitated sperm reaches the ovum, it is able to penetrate this layer with the assistance of hyaluronidase enzymes present on the surface of the sperm.
12.
The venom of " Apis mellifera " ( Honeybee ) contains several biologically-active peptides and two enzymes, one of which is a hyaluronidase.
13.
The first stage is the penetration of corona radiata, by releasing hyaluronidase from the acrosome to digest cumulus cells surrounding the oocyte and exposing acrosin attached to the inner membrane of the sperm.
14.
In addition to these primary modes of alternative splicing, there are two other main mechanisms by which different mRNAs may be generated from the same gene; multiple Schematic cutoff from 3 splicing structures in the murine hyaluronidase gene.
15.
More than a dozen peptides and other substances have been isolated from the Gila monster's venom, including hyaluronidase, serotonin, phospholipase A 2, and several kallikrein-like glycoproteins responsible for the pain and edema caused by a bite.
16.
It is negative for clumping factor, coagulase, hyaluronidase, arginine dihydrolase, ornithine decarboxylase, acetoin, arginine arylamidase, alpha-and beta-haemolysins, heat-stable and heat-labile nucleases, indole, hydrogen sulphide, and lecithinase.
17.
Response to different epitope spectrums depends on the type of " Polistes " that did the stinging . " P . gallicus " venom was found to be a combination of four major allergens : Ag5 ( antigen 5 ), hyaluronidase, phospholipase, and protease.
18.
However, a handful of biologic medicines, including biosynthetic insulin, growth hormone, glucagon, calcitonin, and hyaluronidase are grandfathered under governance of the Federal Food Drug and Cosmetics Act, because these products were already approved when legislation to regulate biotechnology medicines later passed as part of the Public Health Services Act.
19.
The role of hyaluronidases in cancer has been historically controversial due to contradictory observations, namely that levels of hyaluronidase ( HYAL1 / 2 ) are increased in some cancers ( colorectal, bladder, prostate, breast and brain ), whereas low expression of HYAL1 is correlated with a decrease in survival of pancreatic adenocarcinoma patients.
20.
Brand names of animal-derived hyaluronidase include Hydase TM ( developed and manufactured by PrimaPharm Inc ., distributed by Akorn Inc . ), which has been FDA-approved as a " thimerosal-free " animal-derived hyaluronidase, Vitrase ( Bausch + Lomb / Valeant Pharmaceuticals ), Amphadase ( Amphastar Pharmaceuticals ), and Wydase.
