The major toxins involved in " A . muscaria " poisoning are muscimol ( 3-hydroxy-5-aminomethyl-1-isoxazole, an unsaturated cyclic hydroxamic acid ) and the related amino acid ibotenic acid.
12.
"' Pracinostat "'( "'SB939 "') is an orally bioavailable, small-molecule histone deacetylase ( HDAC ) inhibitor based on hydroxamic acid with potential anti-tumor activity characterized by favorable physicochemical, pharmaceutical, and pharmacokinetic properties.
13.
The toxicity of aspergillic acid is controlled by the hydroxamic acid functionality, and there is little effect on toxicity observed between the differences in the 3 and 6 position side chain substituents.
14.
DIMBOA is a member of a group of hydroxamic acids ( also known as benzoxazinoids ) that serve as a natural defense against a wide range of pests, including insects, pathogenic fungi and bacteria.
15.
"Second-generation " HDIs include the hydroxamic acids vorinostat ( SAHA ), belinostat ( PXD101 ), LAQ824, and panobinostat ( LBH589 ); and the benzamides : entinostat ( MS-275 ), CI994, and mocetinostat ( MGCD0103 ).
16.
The fungus does not require a specific soil but seems to prefer acidic and nutrient-deficient soil . " Suillus luteus " produces hydroxamic acid-based siderophores, which are compounds that can carbon dioxide levels in the atmosphere.
17.
In addition, the cytosolic " N ", " O "-aryl hydroxamic acid acyltransferase enzyme catalyzes the transfer of the acetyl group from the N atom of the N-OH-2-AAF to the O atom of the N-OH group to produce N-acetoxy-2-aminofluorene ( N-OH-2-AF ).
18.
Compounds which increased " SMN2 " activity " in vitro " but did not make it to the clinical stage include growth hormone, various histone deacetylase inhibitors, benzamide M344, hydroxamic acids ( CBHA, SBHA, entinostat, panobinostat, trichostatin A, vorinostat ), prolactin as well as natural polyphenol compounds like resveratrol and curcumin.
19.
The mechanism below begins with an O-acylated hydroxamic acid derivative that is treated with base to form an isocyanate that generates an amine and CO 2 gas in the presence of H 2 O . The hydroxamic acid acid derivative is first converted to its conjugate base by abstraction of a hydrogen by a base.
20.
The mechanism below begins with an O-acylated hydroxamic acid derivative that is treated with base to form an isocyanate that generates an amine and CO 2 gas in the presence of H 2 O . The hydroxamic acid acid derivative is first converted to its conjugate base by abstraction of a hydrogen by a base.
