Dr . Stephen Gyland of Tampa, Florida, suffered from hyperinsulinism and happened on Harris's article in the Journal of the American Medical Association.
12.
Glucose requirements above 10 mg / kg / minute in infants, or 6 mg / kg / minute in children and adults are strong evidence for hyperinsulinism.
13.
"' Congenital hyperinsulinism "'is a medical term referring to a variety of congenital disorders in which hypoglycemia is caused by excessive insulin secretion.
14.
His research on hyperinsulinism and its control brought international recognition to Harris, including the Distinguished Service Medal, the highest scientific award of the American Medical Association.
15.
Surgical removal of the overactive part of the pancreas is curative with minimal risk when hyperinsulinism is focal or due to a benign insulin-producing tumor of the pancreas.
16.
The principal treatments of hyperinsulinism due to insulin resistance are measures that improve insulin sensitivity, such as weight loss, physical exercise, and drugs such as thiazolidinediones or metformin.
17.
Diazoxide also inhibits the secretion of insulin from the pancreas, thus it is used to counter hypoglycemia in disease states such as insulinoma ( a tumor producing insulin ) or congenital hyperinsulinism.
18.
These studies led to research on the effects in nondiabetic patients of an excessive secretion of insulin and his recognition that hyperinsulinism could cause hypoglycemia, a deficiency of sugar in the blood.
19.
When congenital hyperinsulinism is diffuse and refractory to medications, near-total pancreatectomy may be the treatment of last resort, but in this condition is less consistently effective and fraught with more complications.
20.
Insulin levels above 3 ?U / mL are inappropriate when the glucose level is below 50 mg / dL ( 2.8 mM ), and may indicate hyperinsulinism as the cause of the hypoglycemia.
