Conserved domains are available in the hypothetical proteins which need to be compared with the known family domains by which hypothetical protein could be classified into particular protein families even though they have not been in vivo investigated.
12.
P24 is conserved across several " Pseudomonas " species and is consistently located between a hypothetical protein gene and a transcriptional regulator gene ( AsnC family ) in the genomes of these " Pseudomonas " species.
13.
"' Uncharacterized protein C1orf106 "', sometimes referred to as "'hypothetical protein LOC55765 "', is a protein of unknown function that in humans is encoded by the " C1orf106 " gene.
14.
The function of hypothetical protein could also be predicted by homology modelling, in which hypothetical protein has to align with known protein sequence whose three dimensional structure is known and by modelling method if structure predicted then the capability of hypothetical protein to function could be ascertained computationally.
15.
The function of hypothetical protein could also be predicted by homology modelling, in which hypothetical protein has to align with known protein sequence whose three dimensional structure is known and by modelling method if structure predicted then the capability of hypothetical protein to function could be ascertained computationally.
16.
The function of hypothetical protein could also be predicted by homology modelling, in which hypothetical protein has to align with known protein sequence whose three dimensional structure is known and by modelling method if structure predicted then the capability of hypothetical protein to function could be ascertained computationally.
17.
Further, approaches to annotate function to hypothetical proteins include determination of 3-dimensional structure of these proteins by structural genomics initiatives, understanding the nature and mode of prosthetic group / metal ion binding, fold similarity with other proteins of known functions and annotating possible catalytic site and regulatory site.
18.
CiLV-C2 RNA2 contains five ORFs that potentially encoded five proteins : 15, 7, 61, 32, and 24 kDa, similar to those predicted protein masses for CiLV-C . The 32 kDa protein has a conserved cell-to-cell movement protein domain, and the small hypothetical protein ( 7 kDa ), that is not present in CiLV-C, has a putative trans-membrane domain.
