T 1 AM may be part of a signaling pathway to modulate cardiac function, as the compound can induce negative inotropic effects and decrease cardiac output.
12.
The latter property ( positive chronotropic and inotropic effects ) is particularly important, because other vasodilators used in angina may be counter productive causing coronary steal phenomenon.
13.
In higher concentrations it causes endothelium-independent vasodilation and has a negative inotropic effect on cardiac output function, thus effectively lowering blood pressure and myocardial oxygen consumption.
14.
Non-dihydropyridine calcium channel blockers such as verapamil block the slow inward calcium current in cardiac tissues, thereby having a negatively dromotropic, chronotropic and inotropic effect.
15.
In addition, since SERCA is more active, the next action potential will cause an increased release of calcium, resulting in increased contraction ( positive inotropic effect ).
16.
The mechanism of action is through inhibiting the breakdown and thereby increasing the concentration of cAMP similar to beta adrenoreceptor agonism, resulting in inotropic effects and modest diuretic effects.
17.
Cassaine can be defined as a specific inhibitor of monovalent cation transport and of Na +-K + ATPase; the result being an inotropic effect on cardiac muscle.
18.
Because of the negative inotropic effects of flecainide, it should be used with caution in individuals with depressed ejection fraction, and may worsen congestive heart failure in these individuals.
19.
Noradrenaline ( a . k . a . norepinephrine ) is an inotrope and has a positive inotropic effect on heart muscle, when binding to beta-1 adrenergic receptors on this tissue.
20.
Disopyramide s particular efficacy is due to its potent negative inotropic effects; in head-to-head comparison, it is more effective for gradient reduction than either beta-blocker or verapamil.
