Advances in gene targeting technologies which hijack the homologous recombination mechanics of cells are now leading to the development of a new wave of more accurate, isogenic human disease models.
12.
Such findings demonstrate that heterosis effects, with a genome dosage-dependent epigenetic basis, can be generated in F1 offspring that are genetically isogenic ( i . e . harbour no heterozygosity ).
13.
'Heterosis without hybridity'effects on plant size have been demonstrated in genetically isogenic F1 triploid ( autopolyploid ) plants, where paternal genome excess F1 triploids display positive heterosis, whereas maternal genome excess F1s display negative heterosis effects.
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In a series of mouse mammary isogenic cancer cell lines, the miR-200 family is highly expressed only in the cells that are able to form metastases ( 4T1 cells ) but not in other cells which are unable to colonize ( 4TO7 cells ).
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In isogenic strains where the non-sense mutation is in the middle of either the gene ADE 2 or ADE 1 ( enzymes involved in the pathway ), the [ psi-] strain has either build ups of P-ribosylamino imidazole ( AIR ), or P-ribosylamino imidazolecarboxylate ( CAIR ), respectively.
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The gene will also be transferred with the least amount of backcrosses to cultivars genetically closest to each other, generation similar genetic offspring to the recurrent parent, but with gene Lr37, Genetic distances between near isogenic lines ( NILs ) for a particular gene will also give an indication of how many loci, amplified with molecular techniques, need to be compared in order to locate putative markers linked to the gene.
