Menderes's brother made Menderes marry Asuman as she was pregnant with Ketal's ( Menderes's brother ) baby, Menderes accepted only for his brother.
12.
The structural diversity in the tirandamycin family originates from the different oxidation patterns observed in the bicycic ketal system, and these modifications are determinant features for the bioactivity associated with these molecules.
13.
The ketone group is protected as the ketal "'8 "'with 1, 2-propylene glycol enabling the organic reduction by lithiumaluminiumhydride of both the bromine group and the formyl group.
14.
The cyclizations to form the tetramic acids 2, 4-pyrrolidinedione ring and the bicyclic ketal system, as well as the oxidative transformations in the bicyclic skeleton, were suggested but further experimental evidence was needed.
15.
Normally, you protect a ketone by using something like Ethylene glycol to form the cyclic ketal; however the reverse is perfectly valid, you can do a protection of vicinal diols by using a simple ketone, like acetone.
16.
The tirandamycins are a small group of natural products that contain a bicyclic ketal system and a tetramic acid moiety, the latter of which is found in different natural products from a variety of sources and which is characterized by a 2, 4-pyrrolidinedione ring system.
17.
The structure of pinnatoxin is composed of a cyclic imine ( A ring ) spirolinked to a cyclohexene ring ( G ring ), a dispiro 6, 5, 6 tricyclic ketal at C12-C23 ( rings B, C, D ), a bridged bicyclic ketal at C25-C30 ( rings E, F ) and a 27-membered macrocyclic ring spanning C5-C31.
18.
The structure of pinnatoxin is composed of a cyclic imine ( A ring ) spirolinked to a cyclohexene ring ( G ring ), a dispiro 6, 5, 6 tricyclic ketal at C12-C23 ( rings B, C, D ), a bridged bicyclic ketal at C25-C30 ( rings E, F ) and a 27-membered macrocyclic ring spanning C5-C31.
