The replication of the kinetoplast occurs simultaneously to the duplication of the adjacent flagellum and just prior to the topoisomerase II . The free minicircles are released into a region between the kinetoplast and the mitochondrial membrane called the kinetoflagellar zone ( KFZ ).
12.
The replication of the kinetoplast occurs simultaneously to the duplication of the adjacent flagellum and just prior to the topoisomerase II . The free minicircles are released into a region between the kinetoplast and the mitochondrial membrane called the kinetoflagellar zone ( KFZ ).
13.
The mitochondrial genome of the " Trypanosoma ", as well as of other kinetoplastids, known as the kinetoplast, is made up of a highly complex series of catenated circles and minicircles and requires a cohort of proteins for organisation during cell division.
14.
"' Kinetoplastida "'( or "'Kinetoplastea "', as a class ) is a group of flagellated protists belonging to the phylum Euglenozoa, and characterised by the presence of an organelle with a large massed DNA called kinetoplast ( hence the name ).
15.
This was first observed in trypanosomatid kinetoplast DNA . Typical sequences which cause this contain stretches of 4-6 " T " and " A " residues separated by " G " and " C " rich sections which keep the A and T residues in phase with the minor groove on one side of the molecule.
16.
Whilst not historically regarded as " T . brucei " subspecies due to their different means of transmission, clinical presentation, and loss of kinetoplast DNA, genetic analyses reveal that " T . equiperdum " and " T . evansi " are evolved from parasites very similar to " T . b . brucei ", and are thought to be members of the " brucei " clade.
