It has been hypothesized, but not proved, that LANCL1 might catalyze formation of glutathione-lanthionine conjugates in a pathway leading to lanthionine ketimine.
12.
It has been hypothesized, but not proved, that LANCL1 might catalyze formation of glutathione-lanthionine conjugates in a pathway leading to lanthionine ketimine.
13.
However, class II, III, and IV lanthipeptides have bifunctional lanthionine synthetases in their gene clusters, meaning a single enzyme carries out both dehydration and cyclization steps.
14.
It has 34 amino acid residues, including the uncommon amino acids lanthionine ( Lan ), methyllanthionine ( MeLan ), didehydroalanine ( Dha ), and didehydroaminobutyric acid ( Dhb ).
15.
"' Lantibiotics "'are a class of peptide antibiotics that contain the characteristic polycyclic thioether amino acids lanthionine or methyllanthionine, as well as the 2-aminoisobutyric acid.
16.
Beside its neurotrophic effects, lanthionine ketimine and its ester LKE reportedly protect neurons against oxidative stress and inhibit the activation of microglia ( brain macrophages ) triggered by exposure to inflammatory cytokines.
17.
This neurotrophic activity may occur through interaction of lanthionine ketimine with a protein called collapsin response protein-2 ( CRMP2, also known as dihydropyrimidinase-like protein-2 or DPYSL2 ).
18.
Lanthionine ketimine and a synthetic, cell-penetrating ester derivative called lanthionine ketimine-5-ethyl ester ( LKE ) reportedly potentiate growth factor-dependent extension of neuron processes ( neurites ) in cell culture.
19.
Lanthionine ketimine and a synthetic, cell-penetrating ester derivative called lanthionine ketimine-5-ethyl ester ( LKE ) reportedly potentiate growth factor-dependent extension of neuron processes ( neurites ) in cell culture.
20.
A variety of syntheses of lanthionine have been published including sulfur extrusion from cystine, ring opening of serine ?-lactone, The sulfur extrusion method is, however, the only pathway for lanthionine that has been employed in the total synthesis of a lantibiotic.
