The first lymph sacs to appear are the paired jugular lymph sacs at the junction of the internal jugular and subclavian veins.
12.
"' Lymph sacs "'are a part of the development of the human lymphatic system, known as lymphangiogenesis.
13.
Many experiments involving mice have proven the importance of the " Prox1 " transcription factor in the development of primitive lymph sacs.
14.
Each jugular lymph sac retains at least one connection with its jugular vein, the left one developing into the superior portion of the thoracic duct.
15.
Following the ballooning, there is the process of pinching, which separates the "'lymph sacs "'from the venous system.
16.
Studies have shown that the development of "'lymph sacs "'occurs through swelling and outgrowth of pre-lymphatic clusters from the cardinal vein.
17.
A range of non-opioid drugs administered through the dorsal lymph sac of Northern leopard frogs has demonstrable analgesic effects, established by using the acetic acid test.
18.
With the exception of the anterior part of the sac from which the cisterna chyli develops, all lymph sacs become invaded by mesenchymal cells and are converted into groups of lymph nodes.
19.
It is believed that the "'lymph sacs "'are directly connected to the venous system and that the venous components and lymphatic components communicate through a small hole.
20.
However, regardless of the presence of these markers, it appears that only the subset of endothelial cells that begin to express " Prox1 " form the undeveloped lymph sacs.
