Hep G2 is a alpha 2-macroglobulin, alpha 1-antitrypsin, transferrin, and plasminogen.
12.
However, alpha2-macroglobulin-like-1 can also be detected in patients with toxic epidermal necrosis.
13.
Human alpha-2-macroglobulin is composed of four identical subunits bound together by-S-S-bonds.
14.
Alpha-2-macroglobulin is able to inactivate an enormous variety of proteinases ( including aspartic-and metalloproteinases ).
15.
These discoveries may link alpha-2-macroglobulin and its receptors, one of them being ApoER2, to Alzheimer s disease.
16.
The alpha-2-macroglobulin molecule is synthesized mainly in liver, but also locally by macrophages, fibroblasts, and adrenocortical cells.
17.
In addition to tetrameric forms of alpha-2-macroglobulin, dimeric, and more recently monomeric aM protease inhibitors have been identified.
18.
The exposure of this receptor binding domain allows the ?2-macroglobulin protease complex to bind to clearance receptors and be removed from circulation.
19.
As a response to hypoproteinemia the liver commences a compensatory mechanism involving the synthesis of proteins, such as alpha-2 macroglobulin and lipoproteins.
20.
Poot et al . 2013 determined that immunoprecipitation for antibodies against envoplakin and periplakin or alpha2-macroglobulin-like 1 is the most sensitive test.
