The maximum tolerated dose differed between Asian and Caucasian populations ( 80 mg / m2 and 25 mg / m2 respectively ), perhaps due to differences in CYP2A6 genotype.
12.
The dosage used in the study was eight times greater than the so-called maximum tolerated dose, the amount above which tissue damage occurs even from innocent substances because of the high concentration.
13.
This is continued until pre-calculated pharmacokinetic safety levels are reached, or intolerable side effects start showing up ( at which point the drug is said to have reached the maximum tolerated dose ( MTD ) ).
14.
The "'maximum tolerated dose "'( MTD ) refers to the highest dose of a radiological or test subjects ( and, among other things, the cost of testing ), to detect an effect that might occur only rarely.
15.
They concluded that, at doses up to internationally accepted standards for a maximum tolerated dose, PBO is not considered to be carcinogenic in the mouse or rat, thus leading to the conclusion that PBO is not carcinogenic to humans.
16.
The authors note that nonetheless, the starting dose will not exceed 33 % of the maximum tolerated dose ( MTD ) identified in the single dose groups ( or 33 % of the maximum administered dose if the MTD is not reached ).
17.
It is worth noticing however that, when comparing lenalidomide and pomalidomide, clinical relevance of higher in vitro potency is unclear since maximum tolerated dose of pomalidomide is 2 mg daily compared to 25 mg for lenalidomide, leading to 10-100 times lower plasma drug concentration of pomalidomide.
