The killing rate was 450, 000 bacteria per square centimetre per minute over the first three hours of exposure or 810 times the minimum dose needed to infect a person with " S . aureus ", and 77, 400 times that of " P . aeruginosa ".
12.
This may also be due to the RDA being too low for other fat soluble vitamins e . g . vitamin D . The minimum dose of vitamin D that is thought to be capable of producing toxicity is about 40, 000 IU / day for many weeks ( although the lowest dose that has been observed to actually produce toxicity is 77, 000 IU / day ).
13.
Patients suffering from WE should be given a minimum dose of 500 mg of Thiamine hydrochloride, delivered by infusion over a 30-minute period for two to three days . If no response is seen then treatment should be discontinued but for those patients that do respond, treatment should be continued with a 250 mg dose delivered intravenously or intramuscularly for three to five days unless the patient stops improving.
