Dr . Bryan Brewer, chief of the molecular disease branch at the National Heart, Lung and Blood Institute, said, " No one has ever seen anything like this in this amount of time ."
12.
This was introduced in November 1949, with the seminal paper, " Sickle Cell Anemia, a Molecular Disease ", in " Science " magazine, Linus Pauling, Harvey Itano and their collaborators laid the groundwork for establishing the field of molecular medicine.
13.
Pauling reinterpreted the large body of research on vitamin C based on comparative studies of the biochemical genetics of vitamin C synthesis in different species, as well his own theories about " molecular disease " and recent developments in molecular evolution.
14.
The book characterizes the inability of humans and some other animals to produce vitamin C in terms of evolution and Pauling's concept of " molecular disease " ( first articulated in his 1949 study, " Sickle Cell Anemia, a Molecular Disease " ).
15.
The book characterizes the inability of humans and some other animals to produce vitamin C in terms of evolution and Pauling's concept of " molecular disease " ( first articulated in his 1949 study, " Sickle Cell Anemia, a Molecular Disease " ).
16.
He worked as a postdoctoral fellow in the lab of Linus Pauling at Caltech during 1947-1948, where he, along with Harvey Itano, co-discovered the basis of abnormal hemoglobin in sickle-cell anemia, reported in the famous paper " Sickle Cell Anemia, a Molecular Disease ".
17.
His work in establishing the field of molecular biology; his studies of hemoglobin led to the classification of sickle cell anemia as a molecular disease . " The other scientists on this sheet of stamps included Gerty Cori, biochemist, Edwin Hubble, astronomer, and John Bardeen, physicist.
18.
In collaboration with Linus Pauling, Itano used electrophoresis to demonstrate the difference between normal hemoglobin and sickle cell hemoglobin; their 1949 paper " Sickle Cell Anemia, a Molecular Disease " ( coauthored also with S . J . Singer and Ibert C . Wells ) was a landmark in both molecular medicine and protein electrophoresis.
19.
"The study reported the drug decreased the plaque significantly, " said Dr . H . Bryan Brewer Jr ., the chief for the molecular disease branch at the National Heart, Lung and Blood Institute . " The interesting fact is that it takes years and years to develop hardening of the arteries-and within six weeks of using this drug, you see a significant change ."
20.
Pauling argues that the loss of vitamin C synthesis first arose as a molecular disease, because of a genetic mutation that resulted in the loss of the biochemical capacity to make the vitamin, but because diets of the primate ancestors of humans consisted of high levels of vitamin C from plant sources, the loss of that biochemical mechanism was not harmful and may have even been beneficial.
