In histology, it is very difficult to distinguish it from the other "-blast " cells ( lymphoblast, myeloblast, monoblast, and megakaryoblast ).
12.
Finally, in 1900, the myeloblast, which is the malignant cell in AML, was characterized by Otto Naegeli, who divided the leukemias into myeloid and lymphocytic.
13.
CFU-GEMM gives rise to CFU-GM ( leading to monoblasts and myeloblasts ), CFU-Meg ( leading to megakaryoblasts ), and CFU-E ( leading to proerythroblasts ).
14.
The peripheral blood smear may show myelocytes, metamyelocytes, promyelocytes, and rarely myeloblasts; however, there is a mix of early mature neutrophil precursors, in contrast to the immature forms typically seen in acute leukemia.
15.
Many of the immature blast cells in acute myeloid leukemia have a higher loss of function and thus, a higher inability to carry out normal functions than those more developed immature myeloblast cells in chronic myeloid leukemia ( O Donnell et al . 2012 ).
16.
The criteria for an acute myeloid leukemia case to fall under the M2 subtype is the following : 20 % + nonerythroid cells in peripheral blood or bone marrow are myeloblasts; monocytic precursors are < 20 % in bone marrow and granulocytes are 10 % + of cells ( Mihova, 2013 ).
17.
On the bone marrow biopsy, high grade dysplasia ( RAEB-I and RAEB-II ) may show atypical localization of immature precursors ( ALIPs ) which are islands of immature precursors cells ( myeloblasts and promyelocytes ) localized to the center of the intertrabecular space rather than adjacent to the trabeculae or surrounding arterioles.
18.
According to the widely used WHO criteria, the diagnosis of AML is established by demonstrating involvement of more than 20 % of the blood and / or bone marrow by leukemic myeloblasts, except in the three best prognosis forms of acute myeloid leukemia with recurrent genetic abnormalities ( t ( 8; 21 ), inv ( 16 ), and t ( 15; 17 ) ) in which the presence of the genetic abnormality is diagnostic irrespective of blast percent.
