The use in SIADH actually relies on a side effect; demeclocycline induces nephrogenic diabetes insipidus ( dehydration due to the inability to concentrate urine ) . and, in 1978, a larger study found it to be more effective and better tolerated than lithium carbonate, the only available treatment at the time.
12.
However, diabetes insipidus is either a problem with the production of antidiuretic hormone ( central diabetes insipidus ) or kidney's response to antidiuretic hormone ( nephrogenic diabetes insipidus ), whereas diabetes mellitus causes polyuria via a process called osmotic diuresis, due to the high blood sugar leaking into the urine and taking excess water along with it.
13.
Acquired nephrogenic diabetes insipidus can result from impaired regulation of aquaporin-2 due to administration of lithium salts ( as a treatment for bipolar disorder ), low potassium concentrations in the blood ( hypokalemia ), high calcium concentrations in the blood ( hypercalcemia ), or a chronically high intake of water beyond the normal requirements ( e . g ., due to excessive habitual intake of bottled water or coffee ).
