| 11. | Hence, almost near neutral mutations result in phenotypes that are weakly selected [ 1 ].
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| 12. | Mutations which may have developed allelic variations which code for lactase production into adulthood are simply neutral mutations.
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| 13. | Kimura developed mathematical models of the behavior of neutral mutations subject to random genetic drift in biological populations.
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| 14. | Neutral mutation has become a part of the neutral theory of molecular evolution, proposed in the 1960s.
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| 15. | By this reasoning, the accumulation of these neutral mutations should only be influenced by the mutation rate.
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| 16. | These non-neutral mutations are thought to have special significance evolutionarily when they affect gene regulatory elements.
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| 17. | This theory suggests that neutral mutations are responsible for a large portion of DNA sequence changes in a species.
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| 18. | Many of the mtDNA have far more mutations and at rarely mutated coding sites relative to expectations of neutral mutations.
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| 19. | Therefore, the neutral mutation rate in individual organisms should match the molecular evolution rate in species over evolutionary time.
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| 20. | Hiroshi Akashi more recently proposed a bimodal model for the DFE, with modes centered around highly deleterious and neutral mutations.
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