Bearers of null alleles would be expected to be poor metabolizers of several drugs which are CYP2C19 * 2 or CYP2C19 * 3 substrates.
12.
If a mutation occurs in the annealing site, then the marker can no longer be used and the allele is turned into a null allele.
13.
A null allele is a gene variant that lacks the gene's normal function because it either is not expressed, or the expressed protein is inactive.
14.
Another definition of "'null allele "'concerning molecular markers, refers to such a marker in the case it can no longer be detected because of a mutation.
15.
One example of a null allele is the'O'blood type allele in the human A, B and O homozygous OO individuals as the lack of any blood antigen.
16.
A genetic null allele can be a protein and RNA null, but can also express normal levels of a gene product that is non-functional due to mutation.
17.
They found that if you have two null alleles ( two copies of a gene variant that doesn't function fully ) then you have an increased likelihood of having red hair.
18.
Probably through a Mexican grandmother, he carries the Duffy null allele, he said, a gene variant that protects against malaria and is very common in sub-Saharan Africans but rare among others.
19.
As one example, the Duffy Null allele ( FY * 0 ) has a frequency of almost 100 % of Sub-Saharan Africans, but occurs very infrequently in populations outside of this region.
20.
So at N1, the first backcross, you will select mice that have one allele that is B6 and the other has to be the null allele, which is on a 129 background.
