The resulting ookinete traverses the mosquito gut wall and encysts on the exterior of the gut wall as an oocyst.
12.
The ookinete moves to the outer wall of the mosquito midgut where it develops over the course of several weeks.
13.
Once through the epithelium, the ookinete enters the basil lamina, and forms an oocyst where meiosis takes place.
14.
Upon traversing the midgut wall, the ookinete embeds into the gut's exterior membrane and develops into an oocyst.
15.
When gametocytes are ingested by a mosquito, the gametocytes enter the mosquito gut where fertilisation occurs forming a zygote known as an ookinete.
16.
The gametocytes mature in the insect midgut into macrogametocytes ( female ) with red-staining nuclei and microgametocytes ( male ) with pale-staining diffuse nuclei : these fuse to form an ookinete.
17.
He further discovered that there were two groups of the parasite, one which are non-motile " granular " ( now called microgametocytes ) and one motile " hyaline " ( macrogametocytes ); and that the motile groups were flagellated cells having four or more arms that could fuse with the non-motile forms ( the process of fertilisation ) to form non-motile bodies called vermicule ( but now called ookinete ).
