| 11. | Opioid-induced hyperalgesia has also been criticized as opioid tolerance.
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| 12. | It is generally regarded as a weak-moderate strength opioid.
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| 13. | It acts as a mixed agonist-?-opioid receptor.
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| 14. | In January 2015, Lesser filed two bills regarding opioid abuse.
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| 15. | Purdue Pharma was a leading player in the pro-opioid campaign.
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| 16. | Opioid drugs like morphine act on that system to block physical pain.
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| 17. | Such opioid rotation is standard practice for managing patients with tolerance development.
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| 18. | Oxycodone is the most widely recreationally used opioid in America.
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| 19. | In vertebrates, neuromodulators that moderate pain by interacting with opioid receptors.
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| 20. | Exactly how causes the release of endogenous opioid peptides is still uncertain.
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