Optic cup morphogenesis is the invagination process occurring after neuroectoderm movement forms the spherical optic vesicle ( Phase 1 ).
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This indicates that morphogenesis of the optic cup occurs independently of external cues from its environment, including presence of lens.
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The ratio of the size of the optic cup to the optic disc ( or cup-to-disc ratio ) is measured to diagnose glaucoma.
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Due to the lack of melanin production in both the retinal pigmented epithelium ( RPE ) and optic cup which, in turn, forms the retina.
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The optic vesicles then develop into the optic cup with the inner layer forming the retina and the outer portion forming the retinal pigment epithelium.
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The inner layer of the optic cup is made of neuroepithelium ( neural retina ), while the outer layer is composed of retinal pigment epithelium ( RPE ).
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In the past, scientists have gotten animals like amphibians to grow eyes on various parts of their body by transplanting the entire embryonic optic cup from one spot to another.
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Retinoic acid generated from vitamin A in the retina plays an essential role in eye development as a secreted paracrine signal which restricts invasion of perioptic mesenchyme around the optic cup.
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During the invagination of the optic cup, the ectoderm begins to thicken and form the lens placode, which eventually separates from the ectoderm to form the lens vesicle at the open end of the optic cup.
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During the invagination of the optic cup, the ectoderm begins to thicken and form the lens placode, which eventually separates from the ectoderm to form the lens vesicle at the open end of the optic cup.
