PBP2a is a variant penicillin-binding protein that imparts the ability of " S . aureus " to be resistant to oxacillin.
12.
These inducible penicillin G, amoxicillin, cephalosporins ( i . e . cefaclor, cefazoline, cefuroxime, and cefdinir ), oxacillin, and most macrolides.
13.
U . S . clinical practice guidelines recommend either nafcillin or oxacillin as the first-line treatment of choice for staphylococcal endocarditis in patients without artificial heart valves.
14.
The class D ?-lactamases ( OXA ), which hydrolyze oxacillin, provide a good example of the variety of mechanisms that can be used to transfer resistance.
15.
Meticillin is no longer manufactured because the more stable and similar penicillins such as oxacillin ( used for clinical antimicrobial susceptibility testing ), flucloxacillin, and dicloxacillin are used medically.
16.
Additionally oxacillin susceptible " Staphylococcus aureus " native valve endocarditis of the right side can also be treated with a short 2 week course of beta lactam antibiotic like nafcillin with or without aminoglycosides
17.
Cubicin was approved after clinical studies with 1, 400 patients showed it was safe and effective, and was equal to such standard drugs as vancomycin, oxacillin and nafcillin in the treatment of complicated skin and skin structure infections.
18.
The ?-lactamase-resistant penicillins ( methicillin, oxacillin, cloxacillin, and flucloxacillin ) were developed to treat penicillin-resistant " S . aureus ", and are still used as first-line treatment.
19.
However, some " M . morganii " strains are resistant to penicillin, ampicillin / sublactam, oxacillin, first-generation and second-generation cephalosporins, macrolides, lincosamides, fosfomycin, colistin, and polymyxin B . The emergence of highly resistant strains of " M . morganii " have been associated with use of third-generation cephalosporins.
