Isoquinolines such as papaverine and noscapine have no significant central nervous system effects, and are not regulated under the Controlled Substances Act.
12.
Papaverine has also been demonstrated to be a selective phosphodiesterase inhibitor for the PDE 10A subtype found mainly in the striatum of the brain.
13.
Partial dehydrogenation of laudanosine will lead to papaverine, the alkaloid found in the opium poppy plant ( " Papaver somniferum " ).
14.
Papaverine is an opium alkaloid used to treat visceral spasms, erectile dysfunction and investigated as antipsychotic drug due to its potency to inhibit phosphodiesterase PDE10A.
15.
In a broader sense, the term isoquinoline is used to make reference to isoquinoline derivatives . 1-Benzylisoquinoline is the structural backbone in naturally occurring alkaloids including papaverine.
16.
For years, doctors treated impotence with vacuum devices fitted over the penis, or with such drugs as papaverine and phentolamine, which were injected into the base of the penis.
17.
"' Papaverine "'( opium poppy, papaverine differs in both structure and pharmacological action from the analgesic ( morphine-related ) opium alkaloids ( opiates ).
18.
"' Papaverine "'( opium poppy, papaverine differs in both structure and pharmacological action from the analgesic ( morphine-related ) opium alkaloids ( opiates ).
19.
The Upjohn system uses a vessel relaxer called prostaglandin E1, but urologists have identified at least two other drugs ( papaverine and phentolamine ) that are equally effective for inducing hourlong erections.
20.
Modern drug therapy for ED made a significant advance in 1983, when British physiologist Giles Brindley dropped his trousers and demonstrated to a shocked Urodynamics Society audience his papaverine-induced erection.
