This reference provides an excellent review of not only the clinical aspects of BS but also the presumed pathogenetic mechanisms brought about by the gene defect.
12.
TFIID is composed of the polyglutamine regions has been suggested as one of the pathogenetic mechanisms underlying a group of neurodegenerative disorders referred to as polyglutamine diseases.
13.
This name for the disease reflects the former pathogenetic model of acne inversa, which is considered inflammation of sweat glands as the primary cause of hidradenitis suppurativa.
14.
A subset may additionally have mutations in the genes CBL, TET2, ASXL1, IDH, IKZF1 or EZH2; the pathogenetic contribution of these mutations is being studied.
15.
Abnormalities in both levels and activity of PKC, found in some chronic neurodegenerative syndromes, lead to the possibility that PKC dysfunction could be involved in the pathogenetic mechanisms of disease.
16.
Consequently, alterations of the gene represent a candidate pathogenetic mechanism of pituitary tumorigenesis especially when considered in terms of interactions with other proteins, growth factors, oncogenes play a rule in tumorigenesis.
17.
MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.
18.
Although alastrim had the same incubation period and pathogenetic stages as smallpox, alastrim is believed to have had a mortality rate of less than 1 %, as compared to smallpox's 30 %.
19.
IgE is known to be elevated in various autoimmune disorders such as Lupus ( SLE ), Rheumatoid Arthritis ( RA ) & psoriasis, and is theorized to be of pathogenetic importance in RA and SLE by eliciting a hypersensitivity reaction.
20.
The intensity of his struggles to get his patients to recall past memories led him to conclude that'there was some force that prevented them from becoming conscious and compelled them to remain unconscious . . . pushed the pathogenetic experiences in question out of consciousness.
