| 11. | Linear plasma concentrations were observed within a normal dosage range and no accumulation occurred.
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| 12. | Interactions include that with grapefruit which increases tacrolimus plasma concentrations.
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| 13. | Proton-pump inhibitors like omeprazole have been found to increase the plasma concentrations of methotrexate.
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| 14. | Peak plasma concentration of the main circulating metabolite, GS-331077 occurred 2 4 hours post-dose.
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| 15. | Peak plasma concentrations ( C max ) occur between 5 and 6 hours post-dose.
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| 16. | The plasma concentrations are increased in human by exercise.
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| 17. | CNS effects typically occur at lower blood plasma concentrations.
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| 18. | Trough plasma concentrations increased proportionally to the daily dose.
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| 19. | Likewise CYP3A4 inducers may reduce plasma concentrations of bosutinib.
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| 20. | Highest blood plasma concentrations are reached after two hours.
|
