The neurotransmitter molecules diffuse across the synaptic cleft to the postsynaptic membrane of the primary sensory neuron, where they elicit an action potential.
12.
Silent synapses release glutamate as do prototypical glutamatergic synapses, but their postsynaptic membranes contain only NMDA and possibly mGlu receptors able to bind glutamate.
13.
In the absence of an action potential, acetylcholine vesicles spontaneously leak into the neuromuscular junction and cause very small depolarizations in the postsynaptic membrane.
14.
The ectodomain then migrates across the synaptic cleft and binds to and activates a member of the EGF-receptor family on the postsynaptic membrane.
15.
Calcium ion diffusion into the presynaptic membrane signals the axon terminal to release quanta to generate either an IPSP or EPSP in the postsynaptic membrane.
16.
The drug blocks the active site of acetylcholinesterase so the enzyme can no longer break down the acetylcholine molecules before they reach the postsynaptic membrane receptors.
17.
The subsequent change in stimulation threshold of the postsynaptic membrane can be enhanced or inhibited, depending on the transmitter chemical involved and the ion permeabilities.
18.
Dok-7 is a postsynaptic protein that binds and activates MuSK protein, which then leads to AChR clustering and typical folding of the postsynaptic membrane.
19.
It may also play a role in ternary complex assembly of synaptic proteins at the postsynaptic membrane and coupling of signal transduction to membrane / cytoskeletal remodeling.
20.
These neurotransmitters are released into the synaptic cleft to bind onto the receptors of the postsynaptic membrane and influence another cell, either in an inhibitory or excitatory way.
