Titus et al . showed that DNA double-strand breaks accumulate with age in humans and mice in primordial follicles.
12.
Primordial follicle initiation and development varies by species; in the canine primordial follicle formation occurs 17 54 days post birth.
13.
Primordial follicle initiation and development varies by species; in the canine primordial follicle formation occurs 17 54 days post birth.
14.
Primordial follicles containing the primary oocyte, arrested at prophase of meiosis I, develop into primary follicle containing cuboidal granulosa cells.
15.
As well as the failure to form primordial follicles, knockout mice also lacked zona pellucida genes Zp1, Zp2, and ZP3 expression.
16.
In the second case one frequent cause is autoimmune ovarian disease which damages maturing follicles, but leaves the primordial follicles intact.
17.
It is believed that premature ovarian failure in humans is caused by FIGLA haploninsuffciency, which disrupts the formation of the primordial follicles.
18.
The cells coat an oocyte like strips of papier-mache wrapped around a balloon, and together they form a structure that biologists call a primordial follicle.
19.
Because primordial follicles can be dormant for up to 50 years in the human, the length of the ovarian cycle does not include this time.
20.
Even though primordial follicles will continue to form, between days 33 and 54 increasing numbers begin to degenerate, along with a decrease in ovarian cortical width.
