PAH is one of three members of the biopterin-dependent aromatic amino acid hydroxylases, a class of monooxygenase that uses tetrahydrobiopterin ( BH 4, a pteridine cofactor ) and a non-heme iron for catalysis.
12.
Some " Russula " species contain pigmented " pteridine " derivatives called " russupteridines " that are not found in the milk-caps . " Sesquiterpenes " are characteristic secondary metabolites of many Russulaceae, especially milk-caps which have been quite intensively studied.
13.
The folate binding pocket is delineated by pteridine-binding cleft, the formyl transfer region and the benzoylglutamate region which bind thepteridine head and a benzoylglutamate tail connected by a formyl bound nitrogen of fTHF . This folate binding region has been the subject of much research because its inhibition by small molecules has led to the discovery of antineoplastic drugs.
