Class 3 semaphorins ( SEMA3s ), originally identified as axon guidance molecules, play a role in remyelination.
12.
Further, the activity of MYRF increases during remyelination, suggesting it has a critical role in this process.
13.
Paclitaxel induces remyelination in a demyelinating mouse in vivo and inhibits hPAD2 in vitro though its methyl ester side chain.
14.
Later, after 3 5 days, oligodendrocyte precursor cells are also recruited to the site and may contribute to remyelination.
15.
Animal studies suggest that when a LINGO1 is inhibited, OPC differentiation and thus remyelination can be promoted at demyelinated sites.
16.
The Wnt-?-Catelin pathway has been shown to also inhibit remyelination when it is dysregulated in the body.
17.
They are named glial scars because they are produced by glial cells, mainly astrocytes, and their presence prevents remyelination.
18.
In a mouse model, it has been shown that testosterone, acting through the AR, is important in remyelination by oligodendrocytes.
19.
These results suggest regulation of Notch signaling as a therapeutic avenue to enhance remyelination in MS . They were recently submitted for publication.
20.
If the failure of endogenous remyelination is due to an unfavorable differentiation environment, then this will have to be addressed prior to transplantation.
