Researchers published PLOS ONE in 2009 speculated that the infamously afflicted Charles II of Spain may have suffered from renal tubular acidosis in tandem with combined pituitary hormone deficiency.
12.
In all cases, renal tubular acidosis results from a failure of the normal renal mechanisms that regulate systemic pH . There are four types of renal tubular acidosis.
13.
In all cases, renal tubular acidosis results from a failure of the normal renal mechanisms that regulate systemic pH . There are four types of renal tubular acidosis.
14.
Some patients can develop renal involvement ( autoimmune tubulointerstitial nephritis ) leading to proteinuria ( excess protein in urine ), urinary concentrating defect, and distal renal tubular acidosis.
15.
One gene is carbonic anhydrase II ( CAII ), which, when mutated, causes osteopetrosis with renal tubular acidosis ( type 3 ) { Sly, 1983 }.
16.
Type 1 is distal renal tubular acidosis and results from a failure of the cortical collecting duct to acidify the urine below pH 5 . { Alper, 2002 }.
17.
Damage to the ?-intercalated cell's ability to secrete acid can result in distal renal tubular acidosis ( RTA type I, classical RTA ) ( reference ).
18.
In patients with low levels of citrate in the urine ( hypocitraturia ) and incomplete distal renal tubular acidosis, treatment with potassium citrate helps prevent the formation of new kidney stones.
19.
Mutations to the a3 isoform result in the human disease infantile malignant osteopetrosis, and mutations to the a4 isoform result in distal renal tubular acidosis, in some cases with sensorineural deafness.
20.
Mutations to the V-ATPase'a4'or'B1'isoforms result in distal renal tubular acidosis, a condition that leads to metabolic acidosis, in some cases with sensorineural deafness.
