In the past strength-duration curves and rheobase determinations were used to assess nerve injury; today, they play a role in clinical identification of many neurological pathologies, including diabetic neuropathy, ALS.
12.
Measurement of chronaxie and rheobase in sural sensory fibers has revealed mild reductions in excitability in diabetics, as evidenced by significant reductions in conduction velocity and chronaxie of sensory fibers with corresponding increases in rheobase.
13.
Measurement of chronaxie and rheobase in sural sensory fibers has revealed mild reductions in excitability in diabetics, as evidenced by significant reductions in conduction velocity and chronaxie of sensory fibers with corresponding increases in rheobase.
14.
When rheobase exceeds the strength of the stimulus, stimulation fails to generate action potentials ( even with large values of t ); thus if the stimulus is too small, the membrane potential never reaches threshold.
15.
Discovering that motor axons have both a lower rheobase and a longer strength-duration time constant in ALS has prompted the conclusion that motor neurons are abnormally excitable in ALS, with properties more like those of sensory neurons.
16.
Despite this limitation, Weiss s equation provides the best fit for strength-duration data and indicates that rheobase and time constant ( chronaxie ) can be measured from the charge duration curve with a very small margin of error.
17.
Experimental observations utilizing threshold measurements to assess excitability of myelinated nerve fibers have indicated that the function of regenerated internodes indeed remains persistently abnormal, with regenerated motor axons displaying increased rheobase and decreased chronaxie changes that are consistent with abnormal active membrane properties.
18.
Mathematically, rheobase is equivalent to half the current that needs to be applied for the duration of chronaxie, which is a strength-duration time constant that corresponds to the duration of time that elicits a response when the nerve is stimulated at twice rheobasic strength.
19.
"' Rheobase "'is a measure of Greek, the root " rhe " translates to " current or flow ", and " basi " means " bottom or foundation " : thus the rheobase is the minimum current that will produce an action potential or muscle contraction.
20.
"' Rheobase "'is a measure of Greek, the root " rhe " translates to " current or flow ", and " basi " means " bottom or foundation " : thus the rheobase is the minimum current that will produce an action potential or muscle contraction.
