Before sulfa came into use there was Arsphenamine } Salvarsan, used starting around 1910 to treat syphilis.
12.
Both salvarsan and neosalvarsan are prodrugs that is, they are metabolised into the active drug in the body.
13.
Ehrlich's discovery of Salvarsan in 1909 for the treatment of syphilis is termed as the first magic bullet.
14.
In that year it was closed after it was discovered that the disease could be cured within days by applying Salvarsan.
15.
Salvarsan was the first organic antisyphilitic, and a great improvement over the inorganic hygroscopic powder that was highly unstable in air.
16.
It became available in 1912 and superseded the more toxic and less water-soluble salvarsan as an effective treatment for syphilis.
17.
An additional problem was that both Salvarsan and Neosalvarsan had to be stored in sealed vials under a nitrogen atmosphere to prevent oxidation.
18.
So did the spectroscope, the discovery of radio waves and " the magic bullet, " salvarsan, to treat syphilis.
19.
There he studied the structure and properties of the popular foreign drug Salvarsan and developed the method of manufacturing a domestic analogue called Arsol.
20.
His laboratory discovered arsphenamine ( Salvarsan ), the first effective medicinal treatment for syphilis, thereby initiating and also naming the concept of chemotherapy.
