The active methylene group is condensed with " p "-methylthiobenzaldehyde, using sodium methoxide as catalyst, and then saponified to give Z ( "'7 "') which in turn oxidized with sodium metaperiodate to sulfoxide "'8 "', the antiinflammatory agent sulindac.
12.
I don't know, but would suggest, that perhaps " green " is being used in the sense of " new, not ripened or matured ", given that it's a soft soap, being incompletely saponified vegetable oil .-Nunh-huh 04 : 51, 17 October 2005 ( UTC)
13.
The oil may be further refined by 1 ) alkali washing, or removing the heavy aromatic carboxylic acids with antibiotic properties, which may cause heartburn, gallbladder and pancreas irritation, and saponifying ) with a base such as sodium carbonate solution until the yellow residue disappears from the watery phase, decanting, and washing with water to remove the base and the saponified components ( and evaporating the solvents ).
14.
In the hot process, the hydroxide and the fat are heated and mixed together at 80 100 �C, a little below boiling point, until saponification is complete, which, before modern scientific equipment, the soapmaker determined by taste ( the sharp, distinctive taste of the hydroxide disappears after it is saponified ) or by eye; the experienced eye can tell when gel stage and full saponification has occurred.
