| 11. | In azamacrocycle chemistry, diacetylpyridines can undergo the same Schiff base condensation with N1-( 3-aminopropyl ) propane-1, 3-diamines.
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| 12. | The Schiff base, which is conjugated to the enzymes pyridinium ring is the focus of the coenzyme activity.
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| 13. | Lysine 69 on ornithine decarboxylase ( ODC ) binds the cofactor pyridoxal phosphate to form a Schiff base.
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| 14. | Ornithine displaces the lysine to form a Schiff base attached to ODC, which decarboxylates to form a quinoid intermediate.
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| 15. | It also functions as the nucleophile during hydrolysis of the enzyme-product Schiff base, leading to the release of pyruvate.
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| 16. | For this step, the Schiff base must be heated to ~ 250 �C for the ring closure to occur.
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| 17. | For example, using aniline as a nucleophilic catalyst, a less populated protonated carbonyl becomes a highly populated protonated Schiff base.
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| 18. | A Schiff base forms between secologanin's aldehyde-group and tryptamine s amine group, from which Glu309 deprotonates tryptamine s carbon 2.
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| 19. | Lys296 is conserved in all known opsins and serves as the site for the Schiff base linkage with the chromophore.
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| 20. | Figure 1 : General mechanism of acetoacetate decarboxylase, proceeding through a Schiff base intermediate and producing acetone and carbon dioxide
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