To reverse " sickling " of red blood cells, patients got oxygen and transfusions of healthy, oxygen-rich blood.
12.
Once in the animals, the genetically altered bone marrow cells produced normal red blood cells and corrected the sickling disease in the mice.
13.
Sickle-cell haemoglobin ( HgbS ) and haemoglobin C with sickling ( HgbSC ) the two most common forms can be identified from there.
14.
"It corrected the sickling problem throughout the bodies of these mice, " said Philippe Leboulch, a Harvard and MIT scientist who led the team.
15.
In theory, he said, this type of hemoglobin might be used to counter a sickling crisis by opening vessels and delivering extra oxygen to nutrient-starved tissues.
16.
With the new model mice, researchers made animals that only produce human hemoglobin, mostly of the sickling variety responsible for diseased blood cells, according to the papers.
17.
This further causes clumping of HbS molecules into rigid fibers, causing " sickling " of the entire red blood cells in the homozygous ( " HbS / HbS " ) condition.
18.
Sickling and sickle cell disease also confer some resistance to malaria parasitization of red blood cells, so that individuals with sickle-cell trait ( heterozygotes ) have a selective advantage in environments where malaria is present.
19.
Some types of injuries are prevented by adhering to proper technique such as correct upper-body positioning, maintaining straight knees when required, keeping body weight centered over the box of the shoes, and avoiding sickling.
20.
Those with only one of the two alleles of the sickle-cell disease are more resistant to malaria, since the infestation of the malaria " Plasmodium " is halted by the sickling of the cells that it infests.
