The hydantoin derivative dantrolene is a spasmolytic agent with a unique mechanism of action outside of the CNS . It reduces skeletal muscle strength by inhibiting the excitation-contraction coupling in the muscle fiber.
12.
Despite little mainstream airplay, several Skinny Puppy releases have charted in North America and Europe, and their influence on Spasmolytic " music video and during the " Too Dark Park " tour.
13.
It was first isolated from bishop's weed ( " Ammi visnaga " ), a plant indigenous to the Mediterranean region which has been used for centuries in Egypt as a spasmolytic.
14.
In experiments with rabbit jejunum, the aqueous-ethanol extract of " C . officinalis " flowers was shown to have both spasmolytic and spasmogenic effects, thus providing a scientific rationale for this traditional use.
15.
"' Diisopromine "'or "'disoprominum "', usually as the hydrochloride salt, is a synthetic spasmolytic which neutralizes spastic conditions of the biliary tract and of the sphincter of Oddi.
16.
Though a live album has never been released, some live recordings from the tour have been featured on other Skinny Puppy releases, namely " Brap : Back and Forth Series 3 & 4 " and the " Spasmolytic " single.
17.
This ability of GABA to inhibit neurotransmitter release from these preparations was not blocked by bicuculline, was not mimicked by isoguvacine, and was not dependent on Cl? all of which are characteristic of the spasmolytic mimicked, in a stereoselective manner, the effect of GABA.
18.
The domain has been found in a variety of extracellular eukaryotic proteins, including protein pS2 ( TFF1 ) a protein secreted by the stomach mucosa; spasmolytic polypeptide ( SP ) ( TFF2 ), a protein of about 115 residues that inhibits gastrointestinal motility and gastric acid secretion; intestinal trefoil factor ( ITF ) ( TFF3 ); " Xenopus laevis " stomach proteins xP1 and xP4; xenopus integumentary mucins A . 1 ( preprospasmolysin ) and C . 1, proteins which may be involved in defense against microbial infections by protecting the epithelia from the external environment; xenopus skin protein xp2 ( or APEG ); Zona pellucida sperm-binding protein B ( ZP-B ); intestinal sucrase-isomaltase ( / ), a vertebrate membrane bound, multifunctional enzyme complex which hydrolyzes sucrose, maltose and isomaltose; and lysosomal alpha-glucosidase ( ).
