In model animals, knockdown of spastic paraplegia 7 by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1.
12.
Hereditary spastic paraplegias ( HSPs ) are a group of inherited neurological disorders which are characterized by progressive spasticity and weakness of the lower extremities.
13.
The term " CRASH ", for " corpus callosum hypoplasia, retardation, adducted thumbs, spastic paraplegia, and hydrocephalus " has also been used to describe L1CAM-related disorders.
14.
Mutations in the L1 protein are the cause of three neurological syndromes known by the acronym CRASH ( corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus ).
15.
Hereditary spastic paraplegia was first described in 1883 by Adolph Str�mpell, a German neurologist, and was later described more extensively in 1888 by Maurice Lorrain, a French physician.
16.
Mutations associated with this gene cause autosomal recessive spastic paraplegia 7, a neurodegenerative disorder that is characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.
17.
Defects in this gene have been reported to cause spastic paraplegia autosomal dominant type 42 ( SPG42 ) in one Chinese family, but not in similar patients of European descent.
18.
A second homozygous enzyme-disabling mutation has been identified in CYP2U1, c . 1A > C / p . Met1 ?, that is associated with < 1 % of hereditary spastic paraplegia sufferers.
19.
While at Sighet, where he was mainly kept isolated from other prisoners, a medical examination found he was suffering from a variety of physical ailments, including spastic paraplegia, hypoesthesia and sphincter of Oddi dysfunction.
20.
The neurologic changes may appear earlier in each subsequent generation and can include abnormal white matter, conductive deafness, and various kinds of paresis, including ataxia, spastic paraplegia, difficulty controlling the eyes, and bladder and bowel disturbances.
