Anemia of chronic disease, hereditary spherocytosis, hereditary hemoglobinopathies ( including some cases of thalassemia minor ) may all present with a normal RDW.
12.
Risk factors for pigment stones include hemolytic anemias ( such as from sickle-cell disease and hereditary spherocytosis ), cirrhosis, and biliary tract infections.
13.
In disorders of erythrocyte shape and / or flexibility, such as hereditary spherocytosis, erythrocytes fail to pass through and get phagocytosed, causing extravascular hemolysis.
14.
Disorders of the proteins in these membranes are associated with many disorders, such as hereditary spherocytosis, hereditary elliptocytosis, hereditary stomatocytosis, and paroxysmal nocturnal hemoglobinuria.
15.
They are most commonly found in immunologically-mediated hemolytic anemias and in hereditary spherocytosis, but the former would have a positive direct Coombs test and the latter would not.
16.
More importantly erythroid AE1 mutations cause 15 25 % of cases of Hereditary spherocytosis ( a disorder associated with progressive red cell membrane loss ), and also cause the hereditary conditions of Hereditary stomatocytosis and Southeast Asian Ovalocytosis
17.
Sickle cell anemia is the most common blood disorder that children can inherit from their parents, but hemophilia, von Willebrand's disease and hereditary spherocytosis ( HS ) are all " in the genes ."
18.
On 15 March 2010, Gerhard Ehninger, head of the German Society for Hematology and Oncology, said that an evaluation of the case points to a light form of a blood anemia called spherocytosis apparently inherited from her father.
19.
:* Hereditary spherocytosis syndromes are a group of inherited disorders characterized by defects in the red blood cell's cell membrane, causing the cells to be small, sphere-shaped, and fragile instead of donut-shaped and flexible.
20.
Hereditary spherocytosis is caused by a variety of molecular defects in the genes that code for the red blood cell proteins spectrin ( beta ), ankyrin, band 3 protein, protein 4.2, and other red blood cell membrane proteins:
