The clinical presentation is dominated by severe sepsis and the formation of microabscesses, and a relationship between disease severity and the expression of the virulence factors Streptolysin S and SPEGdys has been inferred.
12.
Weissmann-during a Cambridge pub discussion with Bangham-first named the structures " liposomes " after the lysosome, which his laboratory had been studying : a simple organelle the structure-linked latency of which could be disrupted by detergents and streptolysins.
13.
Other bioactive RiPPs include the antibiotics cyclothiazomycin and bottromycin, the ultra-narrow spectrum antibiotic plantazolicin, and the cytotoxin patellamide A . Streptolysin S, the toxic virulence factor of " Streptococcus pyogenes ", is also a RiPP . Additionally, human thyroid hormone itself is a RiPP due to its biosynthetic origin as thyroglobulin.
14.
Several toxins and secreted enzymes have been identified in " Streptococcus dysgalactiae ", including the haemolysins Streptolysin O ( SLO ) and Streptolysin S ( SLS ), and a correlation between the expression of SLO and SLS and disease severity has been inferred . " speGdys ", a homolog of the " S . pyogenes " superantigen " speG ", has been documented in some " S . dysgalactiae " strains.
15.
Several toxins and secreted enzymes have been identified in " Streptococcus dysgalactiae ", including the haemolysins Streptolysin O ( SLO ) and Streptolysin S ( SLS ), and a correlation between the expression of SLO and SLS and disease severity has been inferred . " speGdys ", a homolog of the " S . pyogenes " superantigen " speG ", has been documented in some " S . dysgalactiae " strains.
